Angiogenesis Inhibitor

Biochem/physiol Actions

Reversible: no

Product competes with ATP.

Primary TargethEGF-R tyrosine kinase activity

Cell permeable: yes

Target IC₅₀: 54% inhibition at 10 µM against hEGF-R tyrosine kinase activity

General description

A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model ) with a potency that is comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM).

A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model). The potency has been reported to be comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Braud, E., et al. 2003. J. Enzyme Inhib. Med. Chem.18, 243.

Packaging

Packaged under inert gas

10 mg in Plastic ampoule

Warning

Toxicity: Carcinogenic / Teratogenic (D)